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Dr Jason Cafer's Psychopharmacology, Visualize to Memorize medication mascots


Phase II metabolism pharmacokinetic interaction mnemonic by Dr Jason Cafer MD

Phase II reactions typically involve conjugation of a substrate with glucuronic acid. This makes the drug water-soluble and prepped for renal excretion. 

UGT-glucuronosyltransferase Phase I and II metabolism to glucuronic acid by Dr Jason Cafer MD

The responsible enzyme is UDP-glucuronosyltransferase, abbreviated UGT, as in “U Got Tagged” with glucuronic acid. 


Medications metabolized primarily by Phase II are relatively immune to drug interactions. Examples of clinically relevant Phase II interactions are those involving lamotrigine (Lamictal) as a substrate.

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