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Trimipramine (SURMONTIL)
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Trimipramine (Surmontil) is a tertiary amine tricyclic antidepressant approved for depression. Its sedating profile is relevant when depression is accompanied by prominent insomnia.
Mechanism and mnemonic
“Sermon ’til trimming” connects Surmontil with trimipramine. The medication mascot provides a name mnemonic, while the pegged decagon ballicule illustrates receptor pharmacology.
Trimipramine is strongly sedating and anticholinergic. Weight gain and overdose toxicity are important limitations.
Metabolism and key cautions
Trimipramine is a substrate of CYP2C19 and CYP2D6. The interaction avatar provides a visual cue for its metabolic pathway.
Its sedating and anticholinergic effects can increase fall risk. Tricyclic overdose can be fatal.
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