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COBENFY (xanomeline + trospium), related meds—and all things muscarinic—to understand and remember
Cobenfy, xanomeline + trospium, the next-generation antipsychotic is 9 out of 10 a big deal. Understand in context of all things muscarinic

Jason Cafer MD
Sep 30, 20247 min read
3,442 views
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Dr Cafer interview on Precision Health & PGX Podcast
Sneak peak of Cafer's Psychopharmacology 2nd Edition: Medication Mascots, Avatars, and Ballicules (2025)

Jason Cafer MD
May 17, 20241 min read
210 views
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Interaction of the week: Fluoxetine (Prozac) + Amitriptyline
Fluoxetine ↑ amitriptyline x2 and nortriptyline metabolite x9. The danger is arrhythmia. 5-HT toxicity Sx would not be life threatening.

Jason Cafer MD
May 14, 20242 min read
1,111 views
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Is Kratom an Herbal Tramadol?
The closest prescribable comparison to MG may be the atypical opioid tramadol (Ultram). Tramadol is a weak opioid receptor agonist and SNRI.

Jason Cafer MD
Apr 24, 20243 min read
439 views
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BupropiDex is not Auvelity
It's just the dex. This info is intended for prescribers. Auvelity (dextromethorphan hydrobromide + bupropion ER) was approved as a...

Jason Cafer MD
Mar 14, 20243 min read
2,672 views
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Omeprazole (Prilosec) mnemonics, interactions and risk of dementia
Medical mnemonics for omeprazole

Jason Cafer MD
Aug 12, 20233 min read
383 views
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Interaction of the week: Olanzapine (Zyprexa) + Carbamazepine (Tegretol)
Pharmacokinetic Interaction Carbamazepine may decrease the serum concentration of olanzapine by about 50% (25%-71%) by inDuction of...

Jason Cafer MD
Aug 11, 20231 min read
353 views
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Understanding Alpha-2 Agonists: mascots and ballicules for NE, clonidine, dexmedetomidine, etc.
Norepinephrine – endogenous neurotransmitter, α1 > α2 > β receptor agonist Clonidine – imidazoline > α2 receptor agonist Guanfacine –...

Jason Cafer MD
Aug 8, 202316 min read
3,490 views
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Interaction of the week: Mirtazapine (Remeron) + Clonidine
Explanation of the interaction between mirtazapine (Remeron) and clonidine (Catapres)

Jason Cafer MD
Aug 4, 20232 min read
1,830 views
2 comments


Interaction of the week: Atomoxetine (Strattera) + Bupropion (Wellbutrin)
Atomoxetine (Strattera) + Bupropion (Wellbutrin) is a treacherous ADHD combo. I don't prescribe these two together, but it may be...

Jason Cafer MD
Jul 29, 20231 min read
12,626 views
1 comment


Never accelerate lamotrigine titration (and know the UGT interactions)
This post was inspired by the Carlat Podcast: Psychopharm Commandment 4: Lamotrigine Rash. When is it advisable to accelerate the...

Jason Cafer MD
Feb 5, 20232 min read
946 views
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Viloxazine (QELBREE)
If you've subscribed to the PDF of Cafer's Psychopharmacology, now's the time to re-download for bonus content. Qelbree is a strong...

Jason Cafer MD
Jun 3, 20213 min read
1,488 views
1 comment
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