Use code FREEPDF Stay tuned for the 2nd Edition, expected May 2025.

Comparison of -trigine medications suzetrigine and lamotrigine, with mechanisms and mnemonics

Ketogenic diet, an established non-pharmacological treatment for epilepsy may hold therapeutic potential for severe mental illness.

Cobenfy, xanomeline + trospium, the next-generation antipsychotic is 9 out of 10 a big deal. Understand in context of all things muscarinic

Memorize the factors leading to lithium toxicity, focusing on interactions. PDF of visual mnemonics and 99 versions of this mnemonic song.

The song was made with Donna AI Song & Music Maker. It took about 20 takes to get two good-enough versions, which cost approximately $10....

Antibody vs N3pG Aβ is relatively safe but effect size in improved functioning may not be clinically significant, brain atrophy is a concern

The alpha-2 agonist clonidine will soon be available as an ER suspension. The generic clonidine tabs are Catapres (IR) and Kapvay (ER).

Medication mascot, interaction avatar, and ballicule for famotidine. This humble acid blocker may improve symptoms of schizophrenia.

Sneak peak of Cafer's Psychopharmacology 2nd Edition: Medication Mascots, Avatars, and Ballicules (2025)

The herbal supplement R. rosea is an adaptogen with some evidence for generalized anxiety. It's a 4th line option on Osser's GAD algorithm.

Mouthwash kills bacteria that produce nitric oxide (NO), resulting in adverse HTN and ED. NO has been implicated in many psych conditions.

Fluoxetine ↑ amitriptyline x2 and nortriptyline metabolite x9. The danger is arrhythmia. 5-HT toxicity Sx would not be life threatening.

Arachidonic acid (AA), an omega-6 PUFA, may be deficient in bipolar disorder. Bipolar risk is strongly linked to AA-related genes. Lithium ↑

Clozapine's efficacy is from mechanisms other than D2 blocking, e.g., NMDA receptor agonism. The nororcloz metabolite causes salivation.

1-hr of inhaled nitrous oxide is efficacious for depression within 2 hr. NO2 is an NMDA receptor antagonist like (es)ketamine.

Among the commonly prescribed antipsychotics, 3 have moderate risk of QT prolongation: haloperidol, quetiapine, and ziprasidone (24 mascots)

The alpha blocker doxazosin has been proposed as an alternative to prazosin for PTSD due to longer duration of action. Anti-aging effects?

The closest prescribable comparison to MG may be the atypical opioid tramadol (Ultram). Tramadol is a weak opioid receptor agonist and SNRI.

No oral overlap is needed.  No loading dose required. Minimal pain and low incidence of injection site reactions.