Cafer's Psychopharmacology Free PDF download
Use code FREEPDF Stay tuned for the 2nd Edition, expected May 2025.
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Jason Cafer MD
Nov 254 min read
Ketogenic diet for Serious Mental Illness
Ketogenic diet, an established non-pharmacological treatment for epilepsy may hold therapeutic potential for severe mental illness.
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Jason Cafer MD
Sep 307 min read
COBENFY (xanomeline + trospium), related meds—and all things muscarinic—to understand and remember
Cobenfy, xanomeline + trospium, the next-generation antipsychotic is 9 out of 10 a big deal. Understand in context of all things muscarinic
1,929 views0 comments
Jason Cafer MD
Jul 221 min read
Lithium Toxicity is Preventable and Avoidable - Memorize Lithium Interactions
Memorize the factors leading to lithium toxicity, focusing on interactions. PDF of visual mnemonics and 99 versions of this mnemonic song.
272 views0 comments
Jason Cafer MD
Jul 132 min read
"Allergic to Everything but Oxycodone"– AI-produced Medication Mnemonics Song
The song was made with Donna AI Song & Music Maker. It took about 20 takes to get two good-enough versions, which cost approximately $10....
123 views0 comments
Jason Cafer MD
Jul 98 min read
Donanemab (KISUNLA) FDA-approved for Alzheimer's: Should we recommend it?
Antibody vs N3pG Aβ is relatively safe but effect size in improved functioning may not be clinically significant, brain atrophy is a concern
196 views0 comments
Jason Cafer MD
May 303 min read
ONYDA XR for ADHD is pronounced oh nee dah
The alpha-2 agonist clonidine will soon be available as an ER suspension. The generic clonidine tabs are Catapres (IR) and Kapvay (ER).
282 views0 comments
Jason Cafer MD
May 205 min read
Repurposing Famotidine for post-COVID Brain Fog, Antipsychotic-Induced Weight Gain, etc.
Medication mascot, interaction avatar, and ballicule for famotidine. This humble acid blocker may improve symptoms of schizophrenia.
368 views0 comments
Jason Cafer MD
May 171 min read
Dr Cafer interview on Precision Health & PGX Podcast
Sneak peak of Cafer's Psychopharmacology 2nd Edition: Medication Mascots, Avatars, and Ballicules (2025)
175 views0 comments
Jason Cafer MD
May 163 min read
Rhodiola rosea’s Place in the GAD Algorithm
The herbal supplement R. rosea is an adaptogen with some evidence for generalized anxiety. It's a 4th line option on Osser's GAD algorithm.
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Jason Cafer MD
May 153 min read
How Mouthwash may cause Hypertension and Erectile Dysfunction
Mouthwash kills bacteria that produce nitric oxide (NO), resulting in adverse HTN and ED. NO has been implicated in many psych conditions.
313 views0 comments
Jason Cafer MD
May 142 min read
Interaction of the week: Fluoxetine (Prozac) + Amitriptyline
Fluoxetine ↑ amitriptyline x2 and nortriptyline metabolite x9. The danger is arrhythmia. 5-HT toxicity Sx would not be life threatening.
529 views0 comments
Jason Cafer MD
May 122 min read
Arachidonic Acid and Bipolar Disorder
Arachidonic acid (AA), an omega-6 PUFA, may be deficient in bipolar disorder. Bipolar risk is strongly linked to AA-related genes. Lithium ↑
125 views0 comments
Jason Cafer MD
May 112 min read
Clozapine: Mechanisms of its Unique Efficacy and Unusual Constellation of Side Effects
Clozapine's efficacy is from mechanisms other than D2 blocking, e.g., NMDA receptor agonism. The nororcloz metabolite causes salivation.
371 views0 comments
Jason Cafer MD
May 103 min read
Nitrous Oxide for Treatment-Resistant Depression, Potential Advantages Over (Es)ketamine
1-hr of inhaled nitrous oxide is efficacious for depression within 2 hr. NO2 is an NMDA receptor antagonist like (es)ketamine.
184 views0 comments
Jason Cafer MD
May 93 min read
Guide to QT-prolonging medication
Among the commonly prescribed antipsychotics, 3 have moderate risk of QT prolongation: haloperidol, quetiapine, and ziprasidone (24 mascots)
464 views0 comments
Jason Cafer MD
May 82 min read
Doxazosin for PTSD, and does it slow biologic aging?
The alpha blocker doxazosin has been proposed as an alternative to prazosin for PTSD due to longer duration of action. Anti-aging effects?
251 views0 comments
Jason Cafer MD
Apr 243 min read
Is Kratom an Herbal Tramadol?
The closest prescribable comparison to MG may be the atypical opioid tramadol (Ultram). Tramadol is a weak opioid receptor agonist and SNRI.
264 views0 comments
Jason Cafer MD
Apr 142 min read
Advantages and disadvantages of Risvan, the new LAI for schizophrenia
No oral overlap is needed.
No loading dose required.
Minimal pain and low incidence of injection site reactions.
280 views0 comments
Jason Cafer MD
Apr 103 min read
What's with this "GLP-1 Probiotic"?
Akkermansia muciniphila probiotic
202 views0 comments
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