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Arachidonic Acid and Bipolar Disorder
Arachidonic acid (AA), an omega-6 PUFA, may be deficient in bipolar disorder. Bipolar risk is strongly linked to AA-related genes. Lithium ↑

Jason Cafer MD
May 12, 20242 min read


Clozapine: Mechanisms of its Unique Efficacy and Unusual Constellation of Side Effects
Clozapine's efficacy is from mechanisms other than D2 blocking, e.g., NMDA receptor agonism. The nororcloz metabolite causes salivation.

Jason Cafer MD
May 11, 20242 min read


Nitrous Oxide for Treatment-Resistant Depression, Potential Advantages Over (Es)ketamine
1-hr of inhaled nitrous oxide is efficacious for depression within 2 hr. NO2 is an NMDA receptor antagonist like (es)ketamine.

Jason Cafer MD
May 10, 20243 min read


Guide to QT-prolonging medication
Among the commonly prescribed antipsychotics, 3 have moderate risk of QT prolongation: haloperidol, quetiapine, and ziprasidone (24 mascots)

Jason Cafer MD
May 9, 20243 min read


Doxazosin for PTSD, and does it slow biologic aging?
The alpha blocker doxazosin has been proposed as an alternative to prazosin for PTSD due to longer duration of action. Anti-aging effects?

Jason Cafer MD
May 8, 20242 min read


Is Kratom an Herbal Tramadol?
The closest prescribable comparison to MG may be the atypical opioid tramadol (Ultram). Tramadol is a weak opioid receptor agonist and SNRI.

Jason Cafer MD
Apr 24, 20243 min read


Advantages and disadvantages of Risvan, the new LAI for schizophrenia
No oral overlap is needed.
No loading dose required.
Minimal pain and low incidence of injection site reactions.

Jason Cafer MD
Apr 14, 20242 min read


What's with this "GLP-1 Probiotic"?
Akkermansia muciniphila probiotic

Jason Cafer MD
Apr 10, 20243 min read


BupropiDex is not Auvelity
It's just the dex. This info is intended for prescribers. Auvelity (dextromethorphan hydrobromide + bupropion ER) was approved as a...

Jason Cafer MD
Mar 14, 20243 min read


Phenibut, the Gas Station Gabapentinoid and GABA(B) Agonist
Mnemonic nicknames, ballicules, and mascots for phenibut, baclofen, and gabapentin.

Jason Cafer MD
Mar 9, 20245 min read


Electrostatic therapy with the Elosan Cabin C1
Novel adjunctive treatment for chronic pain, not yet evaluated by the FDA.

Jason Cafer MD
Jan 18, 20241 min read


RELEXXII (methylphenidate ER) now available, and here are mascots for all methylphenidate products
Mascot for Relexxii and the other methylphenidate products

Jason Cafer MD
Jan 1, 20242 min read


"Zeps bound lose pounds" - Tirzepatide has been approved for weight loss as ZEPBOUND
See also: Overview of GLP-1 agonists First, I'll introduce the original brand of tirzepatide, MOUNJARO. Tirzepatide (Mounjaro)...

Jason Cafer MD
Nov 9, 20232 min read


5-HT1A receptors and the ballicules that bind them
5-HT1A serotonin receptors are important.

Jason Cafer MD
Oct 22, 20233 min read


Risperidone / Paliperidone LAI conversion tables, and why I'm favoring Uzedy
Equivalent Dose and Drug Conversions: How to convert between doses of risperidone, paliperidone, Uzedy, Perseris, Invega Sustenna, Trinza

Jason Cafer MD
Oct 18, 20232 min read


Pitolisant (WAKIX) approved for Idiopathic Hypersomnia: Mascot and Interaction Avatars
Pitolisant (WAKIX) approved for Idiopathic Hypersomnia: Mascots and Mnemonics

Jason Cafer MD
Oct 12, 20232 min read


New antidepressant gepirone (EXXUA) compared to buspirone (BUSPAR)
Comparison of gepirone (Exxua) and Buspirone (Buspar) with mnemonic mascots and ballicules explaining mechanism of action - psychopharm book

Jason Cafer MD
Oct 1, 20239 min read



Jason Cafer MD
Sep 3, 20231 min read


Interaction of the week: Lamotrigine (Lamictal) + Valproate (Depakote)
Lamotrigine + Valproate interaction Valproate (divalproex / valproic acid) doubles serum levels of lamotrigine by inHibiting UGT enzymes....

Jason Cafer MD
Aug 27, 20231 min read


Donepezil (ARICEPT) mascot
Medical mnemonics for donepezil (Aricept) including drug-drug interactions

Jason Cafer MD
Aug 26, 20232 min read
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